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Buy zyban. Uthors calculate 'odds ratios' of 1.1 for nicotine patch and 2.3 for Zyban compared to placebo at one year - see note at end on 'odds ratios' . Overall efficacy. The figures above are for 'point abstinence' - the number not smoking at a point in time12 months after the start of the trial. 'Continuous abstinence' - the number not smoking during the 12 months - is also used as an indicator and this is generally regarded as a more reliable indicator of the likely long term success of treatment. In the Jorenby et al study, the continuous abstinence figures are: Not smoking during one year Placebo = 5.6% Nicotine patch = 9.8% Zyban = 18.4% Zyban + NRT combination = 22.5% The first thing to note is that the quit rate by this measure is closer to one in five rather than one in three and that this might be a more realistic basis for claims. However, there should always be caution with using a single study to make any generalised claim of efficacy - unpublished continuous abstinence data from t buy zyban
 

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He Hurt et al study suggests a lower efficacy than Jorenby et al. It should also be noted that the Jorenby et al study was conducted in an intensive support setting - a smokers' clinic - and this may be different to the conditions in which Zyban is used in the UK, where it will be prescribed by general practitioners. Comparison with nicotine patches. On making the Zyban to NRT comparison, the efficacy by point abstinence does show twice the efficacy. However, ASH believes it is premature and inappropriate to make this claim, given the current state of the evidence - for the following reasons. A. This is a single study and should be replicated before drawing any conclusions. B. The result for the nicotine patch is very poor = only 1.05 x placebo - odds ratio 1.1. Yet we know that NRT has a large evidence base (about 80 studies) suggesting that it is much more effective than this figure would suggest. So the 'twice as effective' claim is based on an anomalous result for the nicotine patc buy zyban


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buy zyban Ce data from the Hurt et al study suggests a lower efficacy than Jorenby et al. It should also be noted that the Jorenby et al study was conducted in an intensive support setting - a smokers' clinic - and this may be different to the conditions in which Zyban is used in the UK buy zyban, where it will be prescribed by general practitioners. Comparison with nicotine patches. On making the Zyban to NRT comparison buy zyban, the efficacy by point abstinence does show twice the efficacy. However buy zyban, ASH believes it is premature and inappropriate to make this claim buy zyban, given the current state of the evidence - for the following reasons. A. This is a single study and should be replicated b buy zyban.

buy zyban Efore drawing any conclusions. B. The result for the nicotine patch is very poor = only 1.05 x placebo - odds ratio 1.1. Yet we know that NRT has a large evidence base (about 80 studies) suggesting that it is much more effective than this figure would suggest. So the 'twice as effective' claim is based on an anomalous result for the nicotine patch in a single study. Bupropion has only been compared with buy zyban, and combined with buy zyban, one fixed dosage form of NRT - a patch. The result should not be generalised to administration forms intended for ad lib use. C. The Cochrane collaboration undertakes systematic reviews of evidence for the efficacy of smoking cessation treatments. According to the Cochrane review buy zyban, the odds ratio for continuous abstinence with NRT compared to control was 1.72 (95% confidence interval 1.60 to 1.84) buy zyban, The odds ratios for the different forms of NRT were 1.63 for gum buy zyban, 1.77 for patches buy zyban, 2.27 for nasal spray buy zyban, 2.08 for inhaled nicotine and 1.73 for nicotine sublingual tablet. For bupropion buy zyban, the Cochrane review has pooled results of four studies (2 published) and given a combined odds ratio of 2.73. I shall resist translating these figures into a comparison of NRT and bupropion because.... www.update-software.com cochrane cochrane-frame.html D. ... the Cochrane review (1999 issue 3 buy zyban, which is subscriptio.

buy zyban Tments. According to the Cochrane review buy zyban, the odds ratio for continuous abstinence with NRT compared to control was 1.72 (95% confidence interval 1.60 to 1.84) buy zyban, The odds ratios for the different forms of NRT were 1.63 for gum buy zyban, 1.77 for patches buy zyban, 2.27 for nasal spray buy zyban, 2.08 for inhaled nicotine and 1.73 for nicotine sublingual tablet. For bupropion buy zyban, the Cochrane review has pooled results of four studies (2 published) and given a combined odds ratio of 2.73. I shall resist translating these figures into a comparison of NRT and bupropion because.... www.update-software.com cochrane cochrane-frame.html D. ... the Cochrane review (1999 issue 3 buy zyban, which is subscription.

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