cialis levitra vs For ED Modern drug therapy for ED was advanced enormously in 1983 when British physiologist Giles Brindley cialis levitra vs, Ph.D. dropped his trousers and demonstrated to a shocked AUA audience his phentolamine-induced erection. The drug Brindley injected into his penis was a non-specific vasodilator cialis levitra vs, an alpha-blocking agent cialis levitra vs, and the mechanism of action was clearly corporal smooth muscle relaxation. The effect that Brindley discovered cialis levitra vs, established the fundamentals for the later development of specific cialis levitra vs, safe cialis levitra vs, orally-effective drug therapies cialis levitra vs, ie cialis levitra vs, PDE-5 inhibitors. PDE Inhibition and Smooth Muscle Relaxation Phosphodiesterase (PDE) is an enzyme that causes breakdown of cyclic cialis levitra vs.
cialis levitra vs GMP cialis levitra vs, which is the direct intracellular mediator in the nitric oxide (nonadrenergic cialis levitra vs, noncholinergic) pathway. Discovery of this pathway led to a Nobel Prize in 1998 for the scientists responsible. The nitric oxide system causes relaxation of smooth muscle in blood vessel walls cialis levitra vs, ie cialis levitra vs, vasodilation cialis levitra vs, in various organ systems. The direct intracellular mediator of the nitric oxide pathway is cGMP. PDE catalyzes the degradation of cGMP. This pathway is active in numerous organ systems cialis levitra vs, and as of this writing cialis levitra vs, a number of different PDEs are known. The various PDEs differ in their physiologic roles and tissue distribution. Type 5 PDE is concentrated in the penile smooth muscle of the corpus cavernosum cialis levitra vs, where its normal function is to inhibit erection by degradation of cGMP cialis levitra vs, the mediator of erection. Viagra and the new drugs Cialis and Levitra all inhibit PDE-5 cialis levitra vs, which is an inhibitor for corporal smooth muscle relaxation cialis levitra vs, resulting in increased blood flow in the penis in response to sexual stimulation. Comparison of Viagra cialis levitra vs, Cialis cialis levitra vs, & Levitra No head-to-head trial comparing the 3 PDE inhibitors has been performed. However cialis levitra vs, some differences between the 3 are basic: a table has been created to illustrate the major differences. An obvious proviso is that extensive data are available on Viagra (more than 20 million men treat.
cialis levitra vs muscle of the corpus cavernosum cialis levitra vs, where its normal function is to inhibit erection by degradation of cGMP cialis levitra vs, the mediator of erection. Viagra and the new drugs Cialis and Levitra all inhibit PDE-5 cialis levitra vs, which is an inhibitor for corporal smooth muscle relaxation cialis levitra vs, resulting in increased blood flow in the penis in response to sexual stimulation. Comparison of Viagra cialis levitra vs, Cialis cialis levitra vs, & Levitra No head-to-head trial comparing the 3 PDE inhibitors has been performed. However cialis levitra vs, some differences between the 3 are basic: a table has been created to illustrate the major differences. An obvious proviso is that extensive data are available on Viagra (more than 20 million men treate.
cialis levitra vs
cialis levitra vs | | | | | | cialis levitra vs
|