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Cialis vs levitra. -specific vasodilator, an alpha-blocking agent, and the mechanism of action was clearly corporal smooth muscle relaxation. The effect that Brindley discovered, established the fundamentals for the later development of specific, safe, orally-effective drug therapies, ie, PDE-5 inhibitors. PDE Inhibition and Smooth Muscle Relaxation Phosphodiesterase (PDE) is an enzyme that causes breakdown of cyclic GMP, which is the direct intracellular mediator in the nitric oxide (nonadrenergic, noncholinergic) pathway. Discovery of this pathway led to a Nobel Prize in 1998 for the scientists responsible. The nitric oxide system causes relaxation of smooth muscle in blood vessel walls, ie, vasodilation, in various organ systems. The direct intracellular mediator of the nitric oxide pathway is cGMP. PDE catalyzes the degradation of cGMP. This pathway is active in numerous organ systems, and as of this writing, a number of different PDEs are known. The various PDEs differ in their physiologic roles and cialis vs
 

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tissue distribution. Type 5 PDE is concentrated in the penile smooth muscle of the corpus cavernosum, where its normal function is to inhibit erection by degradation of cGMP, the mediator of erection. Viagra and the new drugs Cialis and Levitra all inhibit PDE-5, which is an inhibitor for corporal smooth muscle relaxation, resulting in increased blood flow in the penis in response to sexual stimulation. Comparison of Viagra, Cialis, & Levitra No head-to-head trial comparing the 3 PDE inhibitors has been performed. However, some differences between the 3 are basic: a table has been created to illustrate the major differences. An obvious proviso is that extensive data are available on Viagra (more than 20 million men treated, more than 1100 peer-reviewed articles as of Feb. & 8217;03), but only limited data on Cialis and Levitra. Drs. Gresser and Gleiter from the U. Tubingen in Germany have compared the three drugs via literature review (Eur. J. Med. Res. 7:435, 2002) In brief, effi cialis vs


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cialis vs levitra Ogication Association cialis vs levitra, trial cialis vs levitra, John McConnell"> Erectile Dysfunction (ED) update cialis vs levitra, 2003 Viagra vs the new PDE-5 Inhibitors: Levitra and Cialis Leonard S. Marks cialis vs levitra, M.D. Medical Director cialis vs levitra, USRF Forbes Magazine Compares Viagra & Levitra Hope for Men who Fail Viagra? 4th Quarter cialis vs levitra, 2003--- Two new ED drugs cialis vs levitra, vardenafil (Levitra cialis vs levitra, Bayer) and tadalafil (Cialis cialis vs levitra, Lilly ICOS) cialis vs levitra, have completed extensive clinical testing cialis vs levitra, and both drugs have gained FDA's approval. Both are inhibitors of type 5 phosphodiesterase (PDE-5) cialis vs levitra, thus sharing the same basic mechanism of sildenafil (Viagra cialis vs levitra, Pfizer) cialis vs levitra, which was approved in March cialis vs levitra, 1998. All three are taken orally prior to planned sexual a cialis vs levitra.

cialis vs levitra Ctivity cialis vs levitra, acting to increase blood flow in the penis in response to sexual stimulation. However cialis vs levitra, there are important differences between the three cialis vs levitra, differences that could influence safety cialis vs levitra, specificity cialis vs levitra, duration of action cialis vs levitra, and ultimately cialis vs levitra, public acceptance within this class of drug. Giles Brindley and Drug Therapy for ED Modern drug therapy for ED was advanced enormously in 1983 when British physiologist Giles Brindley cialis vs levitra, Ph.D. dropped his trousers and demonstrated to a shocked AUA audience his phentolamine-induced erection. The drug Brindley injected into his penis was a non-specific vasodilator cialis vs levitra, an alpha-blocking agent cialis vs levitra, and the mechanism of action was clearly corporal smooth muscle relaxation. The effect that Brindley discovered cialis vs levitra, established the fundamentals for the later development of specific cialis vs levitra, safe cialis vs levitra, orally-effective drug therapies cialis vs levitra, ie cialis vs levitra, PDE-5 inhibitors. PDE Inhibition and Smooth Muscle Relaxation Phosphodiesterase (PDE) is an enzyme that causes breakdown of cyclic GMP cialis vs levitra, which is the direct intracellular mediator in the nitric oxide (nonadrenergic cialis vs levitra, noncholinergic) pathway. Discovery of this pathway led to a Nobel Prize in 1998 for the scientists responsible. The nitric oxide system causes relaxation of smooth muscle in blood vessel walls cialis vs levitra, ie cialis vs levitra, vasodilation cialis vs levitra, in various organ systems. The direct intracellular mediat.

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