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Hydrocodone bitartrate acetaminophen. R 5 to 10 mL (elixir, 15 mL) q 4 to 6 hr prn. Children (younger than 12 yr) PO 10 to 15 mg acetaminophen kg dose q 4 hr to max 2.6 g 24 hr. Y-Site Store at room temperature and protect from light. Drug Interactions Anticholinergics May produce paralytic ileus. Carbamazepine, hydantoins, sulfinpyrazone May result in increased risk of hepatotoxicity from acetaminophen. CNS depressants (eg, barbiturates, ethyl alcohol, other narcotics) May cause CNS toxicity. MAO inhibitors May cause additive CNS toxicity; may cause decreased BP. Tricyclic antidepressants, phenzothiazines May cause additive CNS toxicity. Laboratory Test Interactions With Chemstrip bG , Dextrostix , and Visidex II home blood glucose systems, may cause false decrease in mean glucose values. May give false-positive urinary 5-hydroxyindoleacetic acid test. Amylase or lipase may be increased for 24 hr because of narcotic-induced increase in biliary tract pressure. Adverse Reactions Cardiovascular Hypotension; bradycardia. CNS hydrocodone bitartrate

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Lightheadedness; dizziness; sedation; drowsiness; weakness; anxiety; fear; fatigue; dysphoria; psychological dependence; confusion. GI Nausea; vomiting; constipation. Genitourinary Decreased urination; urethral spasm. Respiratory Dyspnea; respiratory depression; irregular breathing. Precautions Pregnancy Category C . Lactation Excreted in breast milk. Children Safety and effectiveness in children have not been established. Hepatic Function Chronic alcoholics should limit acetaminophen intake to less than 2 g day. Special Risk Patients Closely monitor elderly, debilitated patients, and those with conditions accompanied by hypoxia or hypercapnia to avoid decrease in pulmonary ventilation. Also use caution in patients sensitive to CNS depressants. Because of cough suppressant effects, exercise caution when using postoperatively or in patients with pulmonary disease. Sulfite sensitivity Use caution in sulfite-sensitive individuals; some commercial preparations contain sodium bisulfite. Ove hydrocodone bitartrate

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hydrocodone bitartrate acetaminophen Mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Hy-Phen - Tablets 5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Lorcet 10 650 - Tablets 10 mg hydrocodone bitartrate 650 mg acetaminophen Trade Names: Lorcet-HD - Capsules 5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Lorcet Plus - Tablets 7.5 mg hydrocodone bitartrate 650 mg acetaminophen Trade Names: Lortab 5 500 - Tablets 5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Lortab 7.5 500 - Tablets 7.5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Lortab 10 500 - Tablets 10 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Margesic hydrocodone bitartrate acetaminophen.

hydrocodone bitartrate acetaminophen H - Tablets 5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Norco - Tablets 10 mg hydrocodone bitartrate 325 mg acetaminophen Trade Names: Panacet 5 500 - Tablets 5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Stagesic - Capsules 5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: T-Gesic - Capsules 5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Vicodin - Tablets 5 mg hydrocodone bitartrate 500 mg acetaminophen Trade Names: Vicodin ES - Tablets 7.5 mg hydrocodone bitartrate 750 mg acetaminophen Trade Names: Vicodin HP - Tablets 10 mg hydrocodone bitartrate 660 mg acetaminophen Trade Names: Zydone - Tablets 7.5 mg hydrocodone bitartrate 400 mg acetaminophen - Tablets 10 mg hydrocodone bitartrate 400 mg acetaminophen Mechanism of Action Pharmacology Inhibits synthesis of prostaglandins and binds to opiate receptors in CNS and peripherally blocks pain impulse generation; produces antipyresis by direct action on hypothalamic heat-regulating center; causes cough suppression by direct central action in medulla; may produce generalized CNS depression. Indications and Usage Management of mild to moderate pain. Contraindications Hypersensitivity to acetaminophen hydrocodone bitartrate acetaminophen, hydrocodone hydrocodone bitartrate acetaminophen, or similar compounds. Dosage and Administration Varies according to product and strength. Adu.

hydrocodone bitartrate acetaminophen 7.5 mg hydrocodone bitartrate 400 mg acetaminophen - Tablets 10 mg hydrocodone bitartrate 400 mg acetaminophen Mechanism of Action Pharmacology Inhibits synthesis of prostaglandins and binds to opiate receptors in CNS and peripherally blocks pain impulse generation; produces antipyresis by direct action on hypothalamic heat-regulating center; causes cough suppression by direct central action in medulla; may produce generalized CNS depression. Indications and Usage Management of mild to moderate pain. Contraindications Hypersensitivity to acetaminophen hydrocodone bitartrate acetaminophen, hydrocodone hydrocodone bitartrate acetaminophen, or similar compounds. Dosage and Administration Varies according to product and strength. Adul.

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226; Deaths Seen With Fentanyl Narcotic Pain Patch & 8226; FDA Reviews Adult Antidepressant-Suicide Link INDICATIONS For the relief of moderate to moderately severe pain. DOSAGE AND ADMINISTRATION Dosage should be adjusted according to the severity of pain and the response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related. The usual adult dosage (for the 500 mg 5 mg tablet) is one or two tablets every four to six hours as needed for pain. The total 24 hour dose should not exceed 8 tablets. The usual adult dosage (for the 650 mg 7.5 mg tablet) is one tablet every four to six hours as needed for pain. The total 24 hour dose should not exceed 5 tablets. Storage: Store at controlled room temperature 15° to 30° C. (59° to 86° F). Note: As of 12 2002 the following strength combinations are manufactured by Watson Pharmaceuticals, Inc. : HYDROCODONE APAP TABS 10 325 CIII 100s NDC: 00591-0853-01 HYDROCODONE APAP TABS 10 500 CIII 100s (Compare to Lortab Ž*) *Lortab Ž is a registered trademark of Whitby NDC: 00591-0540-01 HYDROCODONE APAP TABS 10 650 CIII 100s (Compare to Lorcet 10 650 Ž*) *Lorcet 10 650 Ž is a registered trademark of Forest Pharmaceuticals NDC: 00591-0503-01 HYDROCODONE APAP TABS 2.5 500 CIII 100s (Compare to Lortab Ž*) *Lortab Ž is a registered trademark of Whitby NDC: 00591-0388-01 HYDROCODONE APAP TABS 5 500 CIII 100s (Compare to Vicodin Ž*) *Vicodin Ž is a registered trademark of Knoll Pharmaceutical NDC: 00591-0349-01 HYDROCODO

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