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Hydrocodone vicodin. Ugs, from morphine and codeine to Dilaudid and hydrocodone. Efficacy testing was rigorously carried out on hundreds of laboratory animals. To find out how well a substance killed pain, Eddy devised a test in which a cat would be immobilized by a series of metal clamps; pressure would then be applied to its tail. A researcher would record how hard and long the pressure was applied before the animal "displayed a response." The animal would then be dosed with any one of a number of compounds. The researcher would then apply the same pressure, say, 25 minutes later. If the animal did not yelp, more pressure would be applied until the it finally "displayed a response." The difference between the first number and the last came to represent the compound's "analgesic effect." Fortunately for science, but unfortunately for the animals, Eddy was a thorough and dogged researcher, performing these experiments thousands of times. The results showed, among other things, that hydrocodone was an effec hydrocodone vicodin
 

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Tive painkiller with predictable side effects. But hydrocodone also stood out from the pack in one remarkable way: It provoked such euphoria in the animals that Eddy felt compelled to warn of its abuse potential. Hydrocodone was a good cough suppressant, he wrote in 1934, but it also "induced euphoria, and therefore there was danger of addiction." It produced "excitation indistinguishable from that produced by morphine in morphine- tolerant rats." There was something else that made hydrocodone different from the other addictive compounds. As Eddy noted: "Its repeated administration to dogs and monkeys leads to the development of tolerance but more slowly than that of morphine or Dilaudid and to the occurrence of abstinence syndromes that are less severe than with the other drugs." Translation: One can become dependent on it without knowing one is dependent on it — until one is really hooked. Eddy never found a nonaddictive analgesic, but hydrocodone and a number of other drugs he teste hydrocodone vicodin


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edit Withdrawal symptoms Withdrawal symptoms are mostly physical, and can range from simple diarrhea and vomiting to cold flashes, muscle pain, bone pain, and restlessness. 13 edit Alcohol and abuse Vicodin's effects of disorientation, relaxation, and euphoria have been tampered with by mixing them with other drugs, but the most common method has been by mixing them with alcohol. Combined, the drunken effects of alcohol are heightened and brought upon faster. The Do It Now Foundation states that, "Vicodin and other prescription narcotics constitute the most-abused group of prescription drugs, according to the National Household Survey, released in 2001. Of the four million Americans who reported misusing prescription drugs the previous year, nearly 65 percent misused prescription Analgesics. Vicodin use has soared in recent years, partly fueled by the fame of its star user base." The number of 12-17 year-old users jumped 127 percent between 1996 and 2000, according to one national survey. 14 edit In popular culture In the TV show House, the lead character Dr. House is portrayed as an addict of Vicodin. The chorus of the Alkaline Trio song "Emma" references Vicodin. Drugs are a common theme in the band's lyrics. The main character in 28 Days makes reference to an addiction to the drug, stating that it is for her back pain. The rapper Eminem makes many references to Vicodin in his music. Comedian Bill Engvall describes an incident in which Vicoden and a Bahama Mama take him to "Vicodenland," in which he forgets his fear of heights and goes parasailing. In the movie, Just Fri

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