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Information on tramadol. Ing dental surgery, tell the doctor or dentist that you are taking tramadol. you should know that this drug may make you drowsy and may affect your coordination. Do not drive a car or operate machinery until you know how this drug affects you. remember that alcohol can add to the drowsiness caused by this drug. The manufacturer states that tramadol should not be taken with alcohol containing beverages. you should know that tramadol may cause dizziness, lightheadedness, and fainting when you get up from a lying position. To avoid this, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. What should I do if I forget a dose?Return to top Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.What side effects can this medication cause?Return to top Tramadol may cause side effects. Tell your information on

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Doctor if any of these symptoms are severe or do not go away: dizziness weakness headache nervousness or anxiety agitation shaking hands that you cannot control increased muscle tightness changes in mood drowsiness blurred vision heartburn or indigestion upset stomach vomiting diarrhea constipation itching sweating flushing dry mouth Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately: hives rash sores on the inside of your mouth, nose, eyes, or throat flu-like symptoms itching difficulty swallowing or breathing swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs fast heartbeat hoarseness difficulty swallowing or breathing changes in urination seeing things or hearing voices that do not exist (hallucinating) seizures If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online at http: www.fda.g information on

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information on tramadol moderately severe pain. It may be used to treat pain caused by surgery and chronic conditions such as cancer or joint pain. Tramadol is in a class of medications called opiate (narcotic) analgesics. It works by decreasing the body's sense of pain.How should this medicine be used?Return to top Tramadol comes as a tablet to take by mouth. It may be taken with or without food. Your doctor may start you on a low dose of tramadol and gradually increase your dose not more often than every 3 days. Tramadol may be taken every 4-6 hours as needed. If you take too much tramadol information on tramadol, you may experience serious side effects.Ask your doctor about the maximum number of table information on tramadol.

information on tramadol Ts that you may take for each dose or for a 24-hour period.Follow the directions on your prescription label carefully information on tramadol, and ask your doctor or pharmacist to explain any part you do not understand. Take tramadol exactly as directed.Tramadol can be habit-forming. Do not take a larger dose information on tramadol, take it more often information on tramadol, or take it for a longer period of time than prescribed by your doctor. Call your doctor if you find that you want to take extra medication or notice any other unusual changes in your behavior or mood. Do not stop taking tramadol suddenly without talking to your doctor. If you suddenly stop taking tramadol information on tramadol, you may experience side effects. Your doctor will probably decrease your dose gradually.If you suddenly stop taking tramadol you may experience withdrawal symptoms such as nervousness; panic; sweating; difficulty falling asleep or staying asleep; runny nose information on tramadol, sneezing information on tramadol, or cough; numbness information on tramadol, pain information on tramadol, burning information on tramadol, or tingling in your hands or feet; hair standing on end; or rarely information on tramadol, hallucinations (seeing things or hearing voices that do not exist). Other uses for this medicineReturn to top This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.What special precautions should I follow?Return to top Before taking tramadol information on tramadol, tell your doctor and pharmacist if you are allerg.

information on tramadol Robably decrease your dose gradually.If you suddenly stop taking tramadol you may experience withdrawal symptoms such as nervousness; panic; sweating; difficulty falling asleep or staying asleep; runny nose information on tramadol, sneezing information on tramadol, or cough; numbness information on tramadol, pain information on tramadol, burning information on tramadol, or tingling in your hands or feet; hair standing on end; or rarely information on tramadol, hallucinations (seeing things or hearing voices that do not exist). Other uses for this medicineReturn to top This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.What special precautions should I follow?Return to top Before taking tramadol information on tramadol, tell your doctor and pharmacist if you are allergi.

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Hine, when given by the IV IM route. Oral doses range from 50–400 mg daily, with up to 600 mg daily when given IV IM. Mechanism of action The mode of action of tramadol has yet to be fully elucidated, but it is believed to work through modulation of the GABAergic, noradrenergic and serotonergic systems. The contribution of non-opioid activity is demonstrated by the analgesic effects of tramadol not being fully antagonised by the μ-opioid receptor antagonist naloxone. Tramadol is marketed as a racemic mixture with a weak affinity for the μ-opioid receptor (approximately 1 6000th that of morphine). The (+)-enantiomer is approximately four times more potent than the (-)-enantiomer in terms of μ-opioid receptor affinity and 5-HT reuptake, whereas the (-)-enantiomer is responsible for noradrenaline reuptake effects (Shipton, 2000). These actions appear to produce a synergistic analgesic effect, with (+)-tramadol exhibiting 10-fold higher analgesic activity than (-)-tramadol (Goeringer et al., 1997). The serotonergic modulating properties of tramadol mean that it has the potential to interact with other serotonergic agents. There is an increased risk of serotonin syndrome when tramadol is taken in combination with serotonin reuptake inhibitors (e.g. SSRIs), since these agents not only potentiate the effect of 5-HT but also inhibit tramadol's metabolism. It is suggested that tramadol could be effective for alleviating symptoms of depression and anxiety because of its action on GABAergic, noradrenergic and serotonergic systems. However, use of the drug for treatment of such di Yahoo!
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