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Lipitor. D 80 mg were 6.4 (-1.4, 14), 8.7(0, 17), 7.8(0, 16), and 5.1 (-2.7, 15), respectively. Additionally, analysis of the pooled data demonstrated consistent and significant decreases in total-C, LDL-C, TG, total-C HDL-C, and LDL-C HDL-C. In three multicenter, double-blind studies in patients with hypercholesterolemia, LIPITOR was compared to other HMG-CoA reductase inhibitors. After randomization, patients were treated for 16 weeks with either LIPITOR 10 mg per day or a fixed dose of the comparative agent (Table 2). TABLE 2. Mean Percent Change from Baseline at End Point (Double-Blind, Randomized, Active-Controlled Trials) Treatment (Daily Dose) N Total C LDL-C Apo B TG HDL-C Non-HDL-C HDL-C Study 1 Atorvastatin 10 mg 707 -27a -36a -28a -17a +7 -37a Lovastatin 20 mg 191 -19 -27 -20 -6 +7 -28 95% CI for Diff1 -9.2, -6.5 -10.7, -7.1 -10.0, -6.5 -15.2, -7.1 -1.7, 2.0 -11.1, -7.1 Study 2 Atorvastatin 10 mg 222 -25b -35b -27b -17b +6 -36b Pravastatin 20 mg 77 -17 -23 -17 -9 +8 -28 95% CI for Di lipitor
 

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Ff1 -10.8, -6.1 -14.5, -8.2 -13.4, -7.4 -14.1, -0.7 -4.9, 1.6 -11.5, -4.1 Study 3 Atorvastatin 10 mg 132 -29c -37c -34c -23c +7 -39c Simvastatin 10 mg 45 -24 -30 -30 -15 +7 -33 95% CI for Diff1 -8.7, -2.7 -10.1, -2.6 -8.0, -1.1 -15.1, -0.7 -4.3, 3.9 -9.6, -1.9 1 A negative value for the 95% Cl for the difference between treatments favors atorvastatin for all except HDL-C, for which a positive value favors atorvastatin. If the range does not include 0, this indicates a statistically significant difference. a Significantly different from lovastatin, ANCOVA, p 0.05 b Significantly different from pravastatin, ANCOVA, p 0.05 c Significantly different from simvastatin, ANCOVA, p 0.05 The impact on clinical outcomes of the differences in lipid-altering effects between treatments shown in Table 2 is not known. Table 2 does not contain data comparing the effects of atorvastatin 10 mg and higher doses of lovastatin, pravastatin, and simvastatin. The drugs compared in the studies summarized in th lipitor


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lipitor F LIPITOR 10 mg day on Time to Occurrence of Major Cardiovascular Event (myocardial infarction lipitor, acute CHD death lipitor, unstable angina lipitor, coronary revascularization lipitor, or stroke) in CARDS. LIPITOR significantly reduced the risk of stroke by 48% (21 events in the LIPITOR group vs 39 events in the placebo group) lipitor, HR 0.52 lipitor, 95% CI (0.31 lipitor, 0.89) (p=0.016) and reduced the risk of MI by 42% (38 events in the LIPITOR group vs 64 events in the placebo group) lipitor, HR 0.58 lipitor, 95.1% CI (0.39 lipitor, 0.86) (p=0.007). There was no significant difference between the treatment groups for angina lipitor, revascularization procedures lipitor, and acute CHD death. There were 61 deaths in the LIPITOR group vs 82 death lipitor.

lipitor S in the placebo group lipitor, (HR 0.73 lipitor, p=0.059). Hypercholesterolemia (Heterozygous Familial and Nonfamilial) and Mixed Dyslipidemia (Fredrickson Types IIa and IIb) LIPITOR reduces total-C lipitor, LDL-C lipitor, VLDL-C lipitor, apo B lipitor, and TG lipitor, and increases HDL-C in patients with hypercholesterolemia and mixed dyslipidemia. Therapeutic response is seen within 2 weeks lipitor, and maximum response is usually achieved within 4 weeks and maintained during chronic therapy. LIPITOR is effective in a wide variety of patient populations with hypercholesterolemia lipitor, with and without hypertriglyceridemia lipitor, in men and women lipitor, and in the elderly. Experience in pediatric patients has been limited to patients with homozygous FH. In two multicenter lipitor, placebo-controlled lipitor, dose-response studies in patients with hypercholesterolemia lipitor, LIPITOR given as a single dose over 6 weeks significantly reduced total-C lipitor, LDL-C lipitor, apo B lipitor, and TG (Pooled results are provided in Table 1). TABLE 1. Dose Response in Patients with Primary Hypercholesterolemia (Adjusted Mean % Change from Baseline)a Dose N TC LDL-C Apo B TG HDL-C Non-HDL-C HDL-C Placebo 21 4 4 3 10 -3 7 10 22 -29 -39 -32 -19 6 -34 20 20 -33 -43 -35 -26 9 -41 40 21 -37 -50 -42 -29 6 -45 80 23 -45 -60 -50 -37 5 -53 aResults are pooled from 2 dose-response studies. In patients with Fredrickson Types IIa and IIb hyperlipoproteinemi.

lipitor Th homozygous FH. In two multicenter lipitor, placebo-controlled lipitor, dose-response studies in patients with hypercholesterolemia lipitor, LIPITOR given as a single dose over 6 weeks significantly reduced total-C lipitor, LDL-C lipitor, apo B lipitor, and TG (Pooled results are provided in Table 1). TABLE 1. Dose Response in Patients with Primary Hypercholesterolemia (Adjusted Mean % Change from Baseline)a Dose N TC LDL-C Apo B TG HDL-C Non-HDL-C HDL-C Placebo 21 4 4 3 10 -3 7 10 22 -29 -39 -32 -19 6 -34 20 20 -33 -43 -35 -26 9 -41 40 21 -37 -50 -42 -29 6 -45 80 23 -45 -60 -50 -37 5 -53 aResults are pooled from 2 dose-response studies. In patients with Fredrickson Types IIa and IIb hyperlipoproteinemia.

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S, poultry, egg whites, and polyunsaturated oils and margarines (corn, safflower, canola, and soybean oils). Avoid foods with excess fat in them such as meat (especially liver and fatty meat), egg yolks, whole milk, cream, butter, shortening, lard, pastries, cakes, cookies, gravy, peanut butter, chocolate, olives, potato chips, coconut, cheese (other than cottage cheese), coconut oil, palm oil, and fried foods.Talk to your doctor about drinking grapefruit juice while taking this medication.What should I do if I forget a dose?Return to top Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.What side effects can this medication cause?Return to top Atorvastatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: diarrhea headache difficulty falling asleep or staying asleep dizziness joint pain sore throat upper respiratory infection Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately: muscle pain, tenderness, or weakness lack of energy fever chest pain swelling of the hands, feet, ankles, or lower legs nausea extreme tiredness unusual bleeding or bruising loss of appetite pain in the upper right part of the stomach flu-like symptoms yellowing of the skin or eyes rash hives itching difficulty breathing or swallowing swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lo

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