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valium P450 enzyme system. It has a biphasic half-life of 1-2 and 2-5 days valium, and has several pharmacologically active metabolites. The main active metabolite of diazepam is desmethyldiazepam (also known as nordazepam or nordiazepam). Diazepam's other active metabolites include temazepam and oxazepam. These metabolites are conjugated with glucuronide valium, and are excreted primarily in the urine. Because of these active metabolites valium, the serum values of diazepam alone are not useful in predicting the effects of the drug. 1 15 Diazepam has a half-life (t1 2α) of 20-50 hours valium, and desmethyldiazepam has a half-life of 30-200 hours. 15 Most of the drug is metabolised; very li valium.
valium Ttle diazepam is excreted unchanged. 13 In humans valium, the protein binding of diazepam is around 98.5%. 1 edit Indications Diazepam is mainly used to treat anxiety valium, insomnia valium, and symptoms of acute alcohol or opiate withdrawal. It is also used as a premedication for inducing sedation valium, anxiolysis or amnesia prior to certain medical procedures (e.g. endoscopy). 1 Diazepam is rarely used as a primary drug for the long-term treatment of epilepsy. This is due to the fact that tolerance to the anticonvulsant effects of diazepam usually develops within 6 to 12 months of treatment valium, effectively rendering it useless for this purpose. 13 Diazepam has a broad spectrum of indications (most of which are off-label) valium, including: Treatment of anxiety valium, panic attacks valium, and states of agitation 1 Treatment of status epilepticus valium, adjunctive treatment of other forms of epilepsy 1 Treatment of the symptoms of alcohol and opiate withdrawal 1 Short-term treatment of insomnia 1 Treatment of tetanus valium, together with other measures of intensive-treatment 16 Initial management of mania valium, together with firstline drugs like lithium valium, valproate or other antipsychotics citation needed Adjunctive treatment (with antidepressants) of depression with symptoms of anxiety citation needed Adjunctive treatment (with antipsychotics) valium, in patients who develop early e.
valium Cations (most of which are off-label) valium, including: Treatment of anxiety valium, panic attacks valium, and states of agitation 1 Treatment of status epilepticus valium, adjunctive treatment of other forms of epilepsy 1 Treatment of the symptoms of alcohol and opiate withdrawal 1 Short-term treatment of insomnia 1 Treatment of tetanus valium, together with other measures of intensive-treatment 16 Initial management of mania valium, together with firstline drugs like lithium valium, valproate or other antipsychotics citation needed Adjunctive treatment (with antidepressants) of depression with symptoms of anxiety citation needed Adjunctive treatment (with antipsychotics) valium, in patients who develop early ex.
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