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Uced mania, even when seemingly not intense, can ruin marriages and destroy careers. All of the features of mania are not required in order to meet the diagnosis of Antidepressant-Induced Mood Disorder with Manic Features. If the individual's mood is "elevated, euphoric, or irritable," the necessary criteria are met. (2) SSRI-induced depression or worsening of depression. In a seemingly paradoxical effect, antidepressants can cause or worsen depression. In controlled clinical trials for Prozac that were conducted by the manufacturer, Eli Lilly and Company, depressed patients taking Prozac attempted suicide more frequently than depressed patients taking placebo (sugar pill) or older antidepressants. (3) SSRI-induced severe anxiety and agitation, especially in a patient already suffering from depression with anxiety and agitation; (4) SSRI-induced obsessions and compulsions that motivate violence toward oneself or others. (5) SSRI-induced akathisia, an internal sensation of agitation or discomfort that drives a person to move about, and also to lose impulse control. During akathisia, the inner experience of agitation includes many unusual physical feelings, such as electricity in the head or body. The person suffering from akathisia typically feels compelled to move the feet when sitting, to stand, or to pace. Akathisia is known to increase the risk of suicide and violence. Severe Adverse Effects After One or Two Doses Dr. Breggin stated that physicians and patients are not aware that many severe adverse drug effects can surface after the first or second dose of any SSRI anti
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