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Zoloft and pregnancy. force in 1996 to ensure pregnancy labeling of medical products is based on sound, scientific information. More research has been done on hypertension, depression, and other conditions that commonly occur in women of childbearing age, but no areas could be considered well studied in pregnancy, Kweder says. "Hypertension is one of the number one problems women bring to pregnancy or develop during pregnancy," she says. "Yet the number of pregnant women who have been in clinical trials for hypertension is only several hundred." This limits treatment options, says Stika. "We'll prescribe an older hypertension drug because its long history hasn't turned up serious safety concerns," she explains. "There may be other drugs that are more effective and better tolerated, but we don't use them because we don't know about their safety. Nor do we always know the appropriate dose for use in pregnancy." Most people think that determining whether a drug causes birth defects is the major concern, but t zoloft and
 

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He knowledge gap doesn't stop there. "We also need more research on basic science and physiology in pregnancy," Stika says. There is a lot to be learned about how a pregnant woman's body changes from one trimester to the next, which can affect drug levels. Pharmacokinetic (PK) studies are needed to help determine accurate dosing, she adds. PK studies show how our bodies absorb, distribute, metabolize, and excrete drugs. Pregnant women have increased blood volume, which forces the heart and kidneys to work harder. Drugs may be cleared through a pregnant woman's kidneys faster than normal. "In an effort to protect the baby, some doctors may err on the side of caution by giving pregnant women a lower dose than for non-pregnant patients," says the FDA's Kennedy. "But because of the physiological changes that occur in pregnancy, there may be times when pregnant women need a higher dose." Making Treatment Decisions So in the absence of adequate human studies, how do health-care professionals zoloft and


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zoloft and pregnancy So influences clinical decisions. For example zoloft and pregnancy, after 24 weeks of pregnancy zoloft and pregnancy, the antibiotic tetracycline can cause permanent staining of a baby's teeth. And ACE (angiotensin converting enzyme) inhibitors zoloft and pregnancy, a group of drugs that treat high blood pressure zoloft and pregnancy, can damage a baby's kidneys in the second and third trimesters of pregnancy. Depending on the risks zoloft and pregnancy, doctors may adapt treatment by switching a pregnant woman to a similar drug that is safer or prescribing medicine only during a certain portion of the pregnancy. "For example zoloft and pregnancy, if a depressed woman is taking lithium zoloft and pregnancy, she may be able to briefly discontinue the medication during the period of the baby's heart form zoloft and pregnancy.

zoloft and pregnancy Ation zoloft and pregnancy, " Conover says. "Lithium use in pregnancy carries a small risk of fetal heart defects." Revamping Pregnancy Labeling Revamping pregnancy labeling is at the core of the FDA's efforts to better guide health-care professionals in making treatment decisions. Since 1975 zoloft and pregnancy, the FDA has required drug labeling to include a subsection on a drug's ability to cause birth defects and other effects on reproduction and pregnancy. Products also must be classified under one of five letter categories--A zoloft and pregnancy, B zoloft and pregnancy, C zoloft and pregnancy, D zoloft and pregnancy, and X (see the chart "Current Categories for Drug Use in Pregnancy"). A public hearing in 1997 revealed that while this category system is a start zoloft and pregnancy, it's confusing and leads to oversimplification. "The letters imply a gradation of risk that doesn't necessarily exist zoloft and pregnancy, " says the FDA's Kweder. People falsely assume that drugs labeled as category X pose the most risk in pregnancy and drugs labeled as A pose the least. But X reflects a benefit-risk judgment zoloft and pregnancy, and drugs in that category may be no more toxic than drugs called C or D. Some drugs zoloft and pregnancy, such as oral contraceptives zoloft and pregnancy, land in Category X simply because there is no reason to use them in pregnancy. And a drug can fall into Category C because there is some medium level of risk based on animal studies zoloft and pregnancy, or because no animal studies have been conducted. Since 1997 zoloft and pregnancy, the FDA ha.

zoloft and pregnancy G and leads to oversimplification. "The letters imply a gradation of risk that doesn't necessarily exist zoloft and pregnancy, " says the FDA's Kweder. People falsely assume that drugs labeled as category X pose the most risk in pregnancy and drugs labeled as A pose the least. But X reflects a benefit-risk judgment zoloft and pregnancy, and drugs in that category may be no more toxic than drugs called C or D. Some drugs zoloft and pregnancy, such as oral contraceptives zoloft and pregnancy, land in Category X simply because there is no reason to use them in pregnancy. And a drug can fall into Category C because there is some medium level of risk based on animal studies zoloft and pregnancy, or because no animal studies have been conducted. Since 1997 zoloft and pregnancy, the FDA has.

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