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Similar lack of knowledge combined with disbelief. The point here is - I believe there could be many instances where patients report interactions or side effects but these reports go no further than their physicians. I think this is a real and difficult to address problem, whether we're talking herbals, supplements, or prescriptions. Mickey Following is a description of serotonin syndrome that is theorized as possible from combining SJW and SSRIs like Zoloft. There have not been actual reports in the medical literature, but this looks like a classic case. ---- From Dynamed.com "Serotonin syndrome results from excessive levels of serotonin activation by more than one concurrent agent such as selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), trazodone, lithium, buspirone, opiates. Characterized by alterations in cognition (agitation, confusion, hypomania), behavior (agitation, restlessness), autonomic function (fever, diarrhea, tremor, diaphoresis (sweating) + neuromuscular function (myoclonus(twitching), ataxia(loss of muscle coordination), hyperreflexia. Patients with serotonin syndrome usually respond within 36 hrs to discontinuation of serotonergic agents" Reference - J Clin Psychopharmacol 1997 Jun;17;208 in QuickScan Reviews in Fam Pract 1998 Feb;22(11);10) Your note that there have not been actual reports in the medical literature of such an interaction is interesting. I have certainly described this in detail to several doctors. Having investigated the reaction myself, I even suggested that it sounded like my reaction fit the descr
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